The weaponisation of fentanyl
This blog posting is an extract from The Drugs Do Work… [PDF] published in CBRNe World (January 2025). Fentanyl is a powerful analgesic belonging to the class of fully synthetic opioids. Its main application is in the pain management of cancer patients and people recovering from major surgery. Paul Janssen, a Belgian pharmacologist focussing his early laboratory research on antispasmodics, anaesthetics and other pain relief medication, initially synthesised fentanyl in 1959 derived from structure–activity relationship studies of pethidine, a member of the phenylpiperidine class of fully synthetic opioids. Thirty years before, German researchers had first prepared pethidine (also known as …